Artikel Jurnal FORMULA OPTIMIZATION OF ORALLY DISINTEGRATING TABLET CONTAINING MELOXICAM NANOPARTICLES

Abstract : Meloxicam is one of
oxicams anti-drugs that are effective to relieve toothaches,
arthritis, dysmenorrhea, and fever. Meloxicam in this study was milled with
High Energy Milling (HEM) method to download its nano size and then direct
compression method was used to produce Orally Disintegrating Tablets (ODT). ODT
is in a minute. It can be
administered without water or chewing and may improve the bioavailability and
effectiveness of the drug, and increase the patient's adherence. The present
Study of the Superficial Disease and Kollidon CL as superdisintegrants,
that were used separately or in combination, on the characteristics of
nanoparticles meloxicam ODT. It is also the best proportion of
the combination between Ac-Di-Sol and Kollidon CL that can produce the optimum
formula of meloxicam ODT. The effects of single or combined superdisintegrants
were evaluated using Simplex Lattice Design (SLD). Ac-Di-Sol (X1) and Kollidon
CL (X2) were independent variables, while the dependent variables were
friability (Y1), disintegrating time (Y2), wetting time (Y3), and percent
meloxicam release after 60 seconds (Y4). Optimization of five nanoparticles
meloxicam ODT formulas was conducted using Design Expert 7.1.5. The combination
of Ac-Di-Sol 4.05mg (X1) and Kollidon CL 10.95mg (X2) in 150mg nanoparticles
meloxicam ODT can produce optimal ODT characteristics. After verification there
was the difference between predicted value and observed value with p value>
0.05.

Keywords : orally
disintegrating tablet (ODT); meloxicam; milling; nanoparticles

Author : Lina Winarti, Lidya
Ameliana, Dwi Nurahmanto

Journal Code: jpfarmasigg170013



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