Artikel Jurnal Hubungan Kadar Feritin Serum dengan Gangguan Fungsi Paru Pasien Thalassemia Mayor Anak


Abstract : Impaired lung function
is a commonly overlooked complication of thalassemia. Excess iron ones
marked elevated serum ferritin levels are thought to be the cause
impaired lung function in thalassemia major patients.

Objectives. Analyze the association of serum ferritin levels with impaired function
lungs of the child's major thalassemia patients as well as determining the limits of serum ferritin levels
which is associated with impaired lung function.

Method. The cross-sectional study was conducted in April-May
2013. Involved 45 children thalassemia major in Thalassemia Polyclinic RS.
Hasan Sadikin, Bandung. Each subject takes anamnesis, physical examination,
serum ferritin levels, and spirometry. Analysis of serum ferritin relationship
with impaired lung function used logistic regression test with consideration
confounding variables and ROC curves to determine the limits of serum ferritin levels
which is associated with impaired lung function.

Outcome. A total of 45 children met the study criteria. Among 45 children,
16 had impaired restrictive lung function with degree of disturbance
varied, 11 children mild interference, 4 moderate, 1 weight, and no one
have impaired lung function obstructive or mixed. Mean of ferritin content
serum group interference function
restrictive lung (7151.88 μg / L) was higher than the normal lung group
(3,450.34 μg / L) and 4,839 μg / L ferritin levels were associated with malfunction
lungs. In patients with major thalassemia children obtained correlation levels of ferritin
serum with impaired lung function (p = 0.000, OR = 50,754).

Conclusion. There was a significant association of serum ferritin levels with
lung function impairment of thalassemia major child and ferritin 4,839 μg / L
is a limitation of ferritin levels associated with impaired lung function.

Keywords: ferritin levels
serum; impaired lung function; thalassemia mayor

Author : Marte Robiul Sani,
Cissy B. Kartasasmita, Lelani Reniarti

Journal Code: jpkedokterandd140767

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